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    8 Year Exporter Aat - Anti-human GDF15 Antibody, Mouse Monoclonal – Bioantibody Featured Image
    • 8 Year Exporter Aat - Anti-human GDF15 Antibody, Mouse Monoclonal – Bioantibody
    • 8 Year Exporter Aat - Anti-human GDF15 Antibody, Mouse Monoclonal – Bioantibody

    8 Year Exporter Aat - Anti-human GDF15 Antibody, Mouse Monoclonal – Bioantibody

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    8 Year Exporter Aat - Anti-human GDF15 Antibody, Mouse Monoclonal – Bioantibody Detail:

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    General Information
    Growth-differentiation factor 15 (GDF15), also known as MIC-1, is a secreted member of the transforming growth factor (TGF)-β superfamily, as a novel antihypertrophic regulatory factor in the heart. GDF-15 / GDF15 is not expressed in the normal adult heart but is induced in response to conditions that promote hypertrophy and dilated cardiomyopathy and it is expressed highly in liver. GDF-15 / GDF15 has a role in regulating inflammatory and apoptotic pathways in injured tissues and during disease processes. GDF-15 / GDF15 is synthesized as precursor molecules that are processed at a dibasic cleavage site to release C-terminal domains containing a characteristic motif of 7 conserved cysteines in the mature protein. GDF-15 / GDF15 overexpression arising from an expanded erythroid compartment contributes to iron overload in thalassemia syndromes by inhibiting hepcidin expression.

    Properties

    Pair Recommendation CLIA (Capture-Detection):
    23F1-5 ~ 6C1-9
    23F1-5 ~ 3A2-1
    Purity >95%, determined by SDS-PAGE
    Buffer Formulation PBS, pH7.4.
    Storage Store it under sterile conditions at -20℃ to -80℃ upon receiving.
    Recommend to aliquot the protein into smaller quantities for optimal storage.

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    Order Information

    Product Name Cat. No Clone ID
    GDF-15 AB0038-1 3A2-1
    AB0038-2 23F1-5
    AB0038-3 6C1-9
    AB0038-4 4D5-8

    Note: Bioantibody can customized quantities per your need.

    Citations

    1.Wollert K C , Kempf T , Peter T , et al. Prognostic Value of Growth-Differentiation Factor-15 in Patients With Non–ST-Elevation Acute Coronary Syndrome[J]. Circulation, 2007, 115(8):962-971.

    2.Kempf T , Haehling S V , Peter T , et al. Prognostic utility of growth differentiation factor-15 in patients with chronic heart failure.[J]. Journal of the American College of Cardiology, 2007, 50(11):1054-1060.

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    8 Year Exporter Aat - Anti-human GDF15 Antibody, Mouse Monoclonal – Bioantibody detail pictures

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