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Anti-human MPO Antibody, Mouse Monoclonal

Short Description:

Purification Affinity-chromatography Isotype Not Determined
Host Species Mouse Species Reactivity Human
Application Immunochromatography (IC)/Chemiluminescent Immunoassay (CLIA)/Latex turbidimetric

Product Detail

Product Tags

Product details

General Information
MPO (myeloperoxidase) is a peroxidase enzyme secreted by activated leukocytes that plays a pathogenic role in cardiovascular disease, mainly by initiating endothelial dysfunction. Myeloperoxidase (MPO) is an important enzyme, which is one of the components of the antibacterial system in neutrophils and monocytes. MPO participates in the inflammatory response in multiple locations in the body, including the mammary glands. Myeloperoxidase (MPO), a specific polymorphonuclear leukocyte enzyme, has been used previously to quantify the number of neutrophils in tissue. MPO activity was found to be linearly related to the number of neutrophil cells. The MPO system plays an important role in the control of infections and the deletion of malignant cells. Nevertheless, alternations in the MPO system can lead to DNA damage and carcinogenesis. Polymorphisms in the MPO gene have been associated with an increased expression of MPO and a higher risk for the development of cancer. Myeloperoxidase (MPO) is one of the major target antigens of antineutrophil cytoplasmic autoantibodies (ANCA) found in patients with small-vessel vasculitis and Pauci-immune necrotizing glomerulonephritis. Myeloperoxidase-anti-neutrophil cytoplasmic antibody (MPO-ANCA) is an autoantibody that is frequently found in patients with vasculitides.

Properties

Pair Recommendation  
CLIA (Capture-Detection):
4D12-3 ~ 2C1-8
4C16-1 ~ 2C1-8
Purity >95%, determined by SDS-PAGE
Buffer Formulation PBS, pH7.4.
Storage Store it under sterile conditions at -20℃ to -80℃ upon receiving.
Recommend to aliquot the protein into smaller quantities for optimal storage.

Competitive Comparison

detail (1)
detail (2)

Order Information

Product Name Cat. No Clone ID
MPO AB0007-1 2C1-8
AB0007-2 4D12-3
AB0007-3 4C16-1

Note: Bioantibody can customized quantities per your need.

Citations

1.Klebanoff, S. J . Myeloperoxidase: friend and foe[J]. J Leukoc Biol, 2005, 77(5):598-625.

2.Baldus, S. Myeloperoxidase Serum Levels Predict Risk in Patients With Acute Coronary Syndromes[J]. Circulation, 2003, 108(12):1440.


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