China OEM Pct - Anti-human Her2 Antibody, Mouse Monoclonal – Bioantibody

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China OEM Pct - Anti-human Her2 Antibody, Mouse Monoclonal – Bioantibody Detail:

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General Information
Human epidermal growth factor receptor 2 (HER2), also known as ErbB2, NEU, and CD340, is a type I membrane glycoprotein and belongs to the epidermal growth factor (EGF) receptor family. HER2 protein cannot bind growth factors due to the lacking of ligand binding domain of its own and autoinhibited constitutively. However, HER2 forms a heterodimer with other ligand-bound EGF receptor family members, therefore stabilizes ligand binding and enhances kinase-mediated activation of downstream molecules. HER2 plays a key role in development, cell proliferation and differentiation. HER2 gene has been reported to associate with malignancy and a poor prognosis in numerous carcinomas, including breast, prostate, ovarian, lung cancers and so on.

Properties

Pair Recommendation	CLIA (Capture-Detection): 14-2~ 15-6 15-6~ 2-10
Purity	>95%, determined by SDS-PAGE
Buffer Formulation	PBS, pH7.4.
Storage	Store it under sterile conditions at -20℃ to -80℃ upon receiving. Recommend to aliquot the protein into smaller quantities for optimal storage.

Order Information

Product Name	Cat. No	Clone ID
Her2	AB0078-1	14-2
	AB0078-2	15-6
	AB0078-3	2-10

Note: Bioantibody can customized quantities per your need.

Citations

1.Krawczyk N, et al. (2009) HER2 status on persistent disseminated tumor cells after adjuvant therapy may differ from initial HER2 status on primary tumor. Anticancer Res. 29(10): 4019-24.

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