The mammalian cell expression system employs mammalian cells such as HEK293 and CHO and enables post-translational modifications, including folding and complex glycosylation, resulting in proteins that closely resemble their natural counterparts in terms of activity. As a result of this distinct advantage, the mammalian cell expression system plays a crucial role in gene discovery, protein structure and function research, and genetic engineering drug development. However, the current mammalian cell expression system has certain limitations, such as long turnaround time and high production costs.