Manufactur standard Rbp4 - Anti- human IGFBP-1 Antibody, Mouse Monoclonal – Bioantibody

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Manufactur standard Rbp4 - Anti- human IGFBP-1 Antibody, Mouse Monoclonal – Bioantibody Detail:

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General Information
IGFBP1, also known as IGFBP-1 and insulin-like growth factor-binding protein 1, is a member of the insulin-like growth factor-binding protein family. IGF binding proteins (IGFBPs) are proteins of 24 to 45 kDa. All six IGFBPs share 50% homology and have binding affinities for IGF-I and IGF-II at the same order of magnitude as the ligands have for the IGF-IR. IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth-promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. IGFBP1 has an IGFBP domain and a thyroglobulin type-I domain. It binds both insulin-like growth factors (IGFs) I and II and circulates in the plasma. The binding of this protein prolongs the half-life of the IGFs and alters their interaction with cell surface receptors.

Properties

Pair Recommendation	CLIA (Capture-Detection): 4H6-2 ~ 4C2-3 4H6-2 ~ 2H11-1
Purity	>95% as determined by SDS-PAGE.
Buffer Formulation	20 mM PB, 150 mM NaCl, 0.1% Proclin 300,pH7.4
Storage	Store it under sterile conditions at -20℃ to -80℃ upon receiving. Recommend to aliquot the protein into smaller quantities for optimal storage.

Competitive Comparison

Bioantibody	Clinically Diagnosed Case		Total
Bioantibody	Positive	Negative	Total
Positive	35	0	35
Negative	1	87	88
Total	36	87	123
Specificity	100%
Sensitivity	97%

Order Information

Product Name	Cat. No	Clone ID
IGFBP-1	AB0028-1	4H6-2
	AB0028-2	4C2-3
	AB0028-3	2H11-1
	AB0028-4	3G12-11

Note: Bioantibody can customized quantities per your need.

Citations

1.Rutanen E M . Insulin-like growth factor binding protein 1: US 1996.

2.Harman, S, Mitchell, et al. Serum Levels of Insulin-Like Growth Factor I (IGF-I), IGF-II, IGF-Binding Protein-3, and Prostate-Specific Antigen as Predictors of Clinical Prostate Cancer[J]. Journal of Clinical Endocrinology & Metabolism, 2000.

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