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OEM manufacturer Tim-1 - Anti- human TIMP1 Antibody, Mouse Monoclonal – Bioantibody

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OEM manufacturer Tim-1 - Anti- human TIMP1 Antibody, Mouse Monoclonal – Bioantibody Detail:

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General Information
TIMP metallopeptidase inhibitor 1, also known as TIMP-1/TIMP1, Collagenase inhibitor 16C8 fibroblast Erythroid-potentiating activity, TPA-S1TPA-induced proteinTissue inhibitor of metalloproteinases 1, is a natural inhibitors of the matrix metalloproteinases (MMPs), a group of peptidases involved in degradation of the extracellular matrix. TIMP-1/TIMP1 is found in fetal and adult tissues. Highest levels are found in bone, lung, ovary and uterus. Complexes with metalloproteinases and irreversibly inactivates them by binding to their catalytic zinc cofactor. TIMP-1/TIMP1 mediates erythropoiesis in vitro; but, unlike IL-3, it is species-specific, stimulating the growth and differentiation of only human and murine erythroid progenitors. In addition to its inhibitory role against most of the known MMPs, the protein is able to promote cell proliferation in a wide range of cell types, and may also have an anti-apoptotic function. Transcription of this protein encoding gene is highly inducible in response to many cytokines and hormones. In addition, the expression from some but not all inactive X chromosomes suggests that this gene inactivation is polymorphic in human females. This encoding gene is located within intron 6 of the synapsin I gene and is transcribed in the opposite direction. Complexes with metalloproteinases and irreversibly inactivates them by binding to their catalytic zinc cofactor. TIMP-1/TIMP1 is Known to act on MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-10, MMP-11, MMP-12, MMP-13 and MMP-16.

Properties

Pair Recommendation CLIA (Capture-Detection):
1D5-5 ~ 3G11-6
1D12-2 ~ 1G3-7
Purity >95% as determined by SDS-PAGE.
Buffer Formulation PBS, pH7.4.
Storage Store it under sterile conditions at -20℃ to -80℃ upon receiving.
Recommend to aliquot the protein into smaller quantities for optimal storage.

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Order Information

Product Name Cat. No Clone ID
TIMP1 AB0034-1 1D5-5
AB0034-2 1D12-2
AB0034-3 1G3-7
AB0034-4 3G11-6

Note: Bioantibody can customized quantities per your need.

Citations

1.Barylski M , Kowalczyk E , Szadkowska I , et al. [Tissue inhibitor of metalloproteinases[J]. Polski Merkuriusz Lekarski Organ Polskiego Towarzystwa Lekarskiego, 2011, 30(178):246-8.

2.Hayakawa T , Yamashita K , Tanzawa K , et al. Growth‐promoting activity of tissue inhibitor of metalloproteinases‐1 (TIMP‐1) for a wide range of cells A possible new growth factor in serum[J]. FEBS Letters, 1992, 298.

3.Haider D G , Karin S , Gerhard P , et al. Serum retinol-binding protein 4 is reduced after weight loss in morbidly obese subjects.[J]. Journal of Clinical Endocrinology & Metabolism(3):1168-71.


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OEM manufacturer Tim-1 - Anti- human TIMP1 Antibody, Mouse Monoclonal – Bioantibody detail pictures

OEM manufacturer Tim-1 - Anti- human TIMP1 Antibody, Mouse Monoclonal – Bioantibody detail pictures


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We support our purchasers with ideal premium quality products and substantial level company. Becoming the specialist manufacturer in this sector, we've acquired rich practical working experience in producing and managing for OEM manufacturer Tim-1 - Anti- human TIMP1 Antibody, Mouse Monoclonal – Bioantibody , The product will supply to all over the world, such as: Naples, India, Brazil, Company name, is always regarding quality as company' s foundation, seeking for development via high degree of credibility , abiding by ISO quality management standard strictly, creating top-ranking company by spirit of progress-marking honesty and optimism.
  • The quality of the products is very good, especially in the details, can be seen that the company work actively to satisfy customer's interest, a nice supplier.
    5 Stars By Novia from Rwanda - 2017.12.31 14:53
    The factory technical staff gave us a lot of good advice in the cooperation process, this is very good, we are very grateful.
    5 Stars By Jane from Bolivia - 2018.05.22 12:13
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