Quality Inspection for In Vitro Diagnostic Solutions - Anti- human CHI3L1 Antibody, human Monoclonal – Bioantibody
Quality Inspection for In Vitro Diagnostic Solutions - Anti- human CHI3L1 Antibody, human Monoclonal – Bioantibody Detail:
Product details
General Information
Chitinase-3-like protein 1 (CHI3L1) is a secreted heparin-binding glycoprotein whose expression is associated with vascular smooth muscle cell migration. CHI3L1 is expressed at high levels in postconfluent nodular VSMC cultures and at low levels in subconfluent proliferating cultures. CHI3L1 is a tissue-restricted, chitin-binding lectin and member of glycosyl hydrolase family 18. In contrast to many other monocyto / macrophage markers, its expression is absent in monocytes and strong induced during late stages of human macrophage differentiation. Elevated levels of CHI3L1 are associated with disorders exhibiting increased connective tissue turnover, such as rheum atoid, arthritis, osteoarthritis, scleroderma, and cirrhosis of liver, but is produced in cartilage from old donors or patiens with osteoarthritis. CHI3L1 is abnormally expressed in the hippocampus of subjects with schizophrenia and may be involved in the cellular response to various environmental events that are reported to increase the risk of schizophrenia.
Properties
| Pair Recommendation |
CLIA (Capture-Detection): 2E4-2 ~ 1G11-14 13F3-1 ~ 1G11-14 |
| Purity | >95%, determined by SDS-PAGE |
| Buffer Formulation | PBS, pH7.4 |
| Storage |
Store it under sterile conditions at -20℃ to -80℃ upon receiving. For long term storage, please aliquot and store it. Avoid repeated freezing and thawing cycles. |
Comparison Analysis
| Bioantibody | clinically diagnosed case | Total | |
| positive | Negative | ||
| positive | 46 | 3 | 49 |
| Negative | 4 | 97 | 101 |
| Total | 50 | 100 | 150 |
| evaluation index | sensitivity | specificity | accuracy |
| 92% | 97% | 95% | |
Order Information
| Product Name | Cat. No | Clone ID |
| CHI3L1 | AB0031-1 | 1G11-14 |
| AB0031-2 | 2E4-2 | |
| AB0031-3 | 3A12-1 | |
| AB0031-4 | 13F3-1 |
Note: Bioantibody can customized quantities per your need.
Citations
1.Kyrgios I , Galli-Tsinopoulou A , Stylianou C , et al. Elevated circulating levels of the serum acute-phase protein YKL-40 (chitinase 3-like protein 1) are a marker of obesity and insulin resistance in prepubertal children[J]. Metabolism-clinical & Experimental, 2012, 61(4):562-568.
2.Yu-Huan M , Li-Ming T , Jian-Ying L I , et al. Evaluation on application of serum chitinase-3-like protein 1,alpha-fetoprotein and ferritin detection to diagnosing hepatocellular carcinoma[J]. Practical Preventive Medicine, 2018.
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Our company aims to operating faithfully, serving to all of our customers , and working in new technology and new machine constantly for Quality Inspection for In Vitro Diagnostic Solutions - Anti- human CHI3L1 Antibody, human Monoclonal – Bioantibody , The product will supply to all over the world, such as: Amman, Lithuania, Germany, Our company has always insisted on the business principle of "Quality, Honest, and Customer First" by which we have won the trust of clients both from at home and abroad. If you are interested in our solutions, you should do not hesitate to contact us for further information.
By Roland Jacka from San Diego - 2018.12.14 15:26
The customer service staff is very patient and has a positive and progressive attitude to our interest, so that we can have a comprehensive understanding of the product and finally we reached an agreement, thanks!
By Victor from Melbourne - 2018.09.23 18:44
