Quality Inspection for In Vitro Diagnostic Solutions - Anti-human PGI Antibody, Mouse Monoclonal – Bioantibody

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Quality Inspection for In Vitro Diagnostic Solutions - Anti-human PGI Antibody, Mouse Monoclonal – Bioantibody Detail:

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General Information
Pepsinogen I, the precursors of pepsin, is produced by the gastric mucosa and released into the gastric lumen and peripheral circulation. Pepsinogen consists of a single polypeptide chain of 375 amino acids with an average molecular weight of 42 kD. PG I (isoenzyme 1-5) is secreted mainly by chief cells in the fundic mucosa, whereas PG II (isoenzyme 6-7) is secreted by the pyloric glands and the proximal duodenal mucosa.
Precursor reflects numbers of stomach surface cells as well as glandular cells, and monitors gastric atrophy indirectly. They are also extraordinarily stable because they perform their jobs under the harsh conditions present in the digestive system. The atrophy of the corpus mucosa leads to low synthesis of pepsinogen I and hence its low release into the serum. Serum pepsinogen I indicates function and states of gastric mucosa.

Properties

Pair Recommendation	CLIA (Capture-Detection): 1C1-3 ~ 1G7-3 1E3-1 ~ 1G7-3
Purity	>95%, determined by SDS-PAGE
Buffer Formulation	20 mM PB, 150 mM NaCl, 0.1% Proclin 300,pH7.4
Storage	Store it under sterile conditions at -20℃ to -80℃ upon receiving. Recommend to aliquot the protein into smaller quantities for optimal storage.

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Order Information

Product Name	Cat. No	Clone ID
PGI	AB0005-1	1C1-3
	AB0005-2	1E3-1
	AB0005-3	1G7-3

Note: Bioantibody can customized quantities per your need.

Citations

1.Sipponen P , Ranta P , Helske T , et al. Serum levels of amidated gastrin-17 and pepsinogen I in atrophic gastritis: an observational case-control study.[J]. Scandinavian Journal of Gastroenterology, 2002, 37(7):785-791.

2.Mangla J C , Schenk E A , Desbaillets L , et al. Pepsin secretion, pepsinogen, and gastrin in Barrett’s esophagus’. Clinical and morphological characteristics[J]. Gastroenterology, 1976, 70(5 PT.1):669-676.

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