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Calprotectin is a protein released by a type of white blood cell called a neutrophil. When there is inflammation in the gastrointestinal (GI) tract, neutrophils move to the area and release calprotectin, resulting in an increased level in the stool. Measuring the level of calprotectin in stool is a useful way to detect inflammation in the intestines.

Intestinal inflammation is associated with inflammatory bowel disease (IBD) and with some bacterial GI infections, but it is not associated with many other disorders that affect bowel function and cause similar symptoms. Calprotectin can be used to help distinguish between inflammatory and non-inflammatory conditions, as well as monitoring disease activity.

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Citations

1.Takashi K , Toshimasa Y . Adiponectin and Adiponectin Receptors[J]. Endocrine Reviews(3):3.

2.Turer A T , Scherer P E . Adiponectin: mechanistic insights and clinical implications[J]. Diabetologia, 2012, 55(9):2319-2326.

3.1. Rowe, W. and Lichtenstein, G. (2016 June 17 Updated). Inflammatory Bowel Disease Workup. Medscape Drugs and Diseases. Available online at http://emedicine.medscape.com/article/179037-workup#c6. Accessed on 1/22/17.

4.2. Walsham, N. and Sherwood, R. (2016 January 28). Fecal calprotectin in inflammatory bowel disease. Clin Exp Gastroenterol. 2016; 9: 21–29. Available online at https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4734737/ Accessed on 1/22/17.